Norepinephrine, also known as norepinephrine, is a drug used to control blood pressure in certain acute hypotensive states and as an adjunct in the treatment of cardiac arrest and deep hypotension.
This medicine is available in the form of an injection, which should only be used under medical advice and its administration must be performed by a health professional.
What is it for
Norepinephrine is a drug indicated to control blood pressure in certain acute hypotensive states, in situations such as pheochromocytomectomy, sympathectomy, polio, myocardial infarction, septicemia, blood transfusion and reactions to medications.
In addition, it can also be used as an aid in the treatment of cardiac arrest and deep hypotension.
How to use
Norepinephrine is a medicine that should only be administered by a healthcare professional, intravenously, in a diluent solution. The dose to be administered must be individualized and determined by the doctor.
Mechanism of action
Norepinephrine is a neurotransmitter with sympathomimetic activity, fast acting, with pronounced effects on alpha-adrenergic receptors and less pronounced on beta-adrenergic receptors. Thus, its most important effect occurs in the elevation of blood pressure, which is a result of its alpha-stimulating effects, which cause vasoconstriction, with reduced blood flow in the kidneys, liver, skin and, often, skeletal muscles.
Who should not use
Noradrenaline should not be used in people who are hypersensitive to the components of the formula or with mesenteric or peripheral vascular thrombosis.
In addition, it should not be given to people who are hypotensive due to a deficiency in blood volume, except as an emergency measure to maintain coronary and cerebral artery perfusion until blood volume replacement therapy can be completed, even during anesthesia with cyclopropane and halothane, as ventricular tachycardia or fibrillation may occur.
Possible side effects
Some side effects that may occur after administration of norepinephrine are ischemic injuries, decreased heart rate, anxiety, temporary headache, difficulty breathing and necrosis at the injection site.
