Pioglitazone hydrochloride is the active substance of an antidiabetic medication indicated to improve glycemic control in people with type II Diabetes Mellitus, either alone or in combination with other medications, such as sulfonylurea, metformin or insulin, when diet and exercise do not are sufficient to control the disease. Know how to identify the symptoms of type II diabetes.
Pioglitazone contributes to the control of blood sugar levels in people with type II diabetes, helping the body to use the insulin produced more effectively.
This medicine is available in doses of 15 mg, 30 mg and 45 mg, and can be purchased in pharmacies for a price of about 14 to 130 reais, depending on the dosage, packaging size and brand or generics chosen.
How to use
The recommended starting dose of pioglitazone is 15 mg or 30 mg once daily, up to a maximum of 45 mg daily.
How it works
Pioglitazone is a drug that depends on the presence of insulin to exert an effect and acts by decreasing insulin resistance in the periphery and in the liver, resulting in an increase in the elimination of insulin-dependent glucose and a decrease in the production of hepatic glucose.
Who should not use
This medicine should not be used in people with hypersensitivity to pioglitazone or any of the components of the formula, in people with current or past history of heart failure, liver disease, diabetic ketoacidosis, history of bladder cancer or presence of blood in the urine.
In addition, pioglitazone should also not be used in pregnant women or in women who are breastfeeding without medical advice.
Possible side effects
The most common side effects that may occur during treatment with pioglitazone are swelling, increased body weight, reduced hemoglobin and hematocrit levels, increased creatine kinase, heart failure, liver dysfunction, macular edema and the occurrence of bone fractures in women.
