- Indications for Voriconazole
- Voriconazole price
- Side Effects of Voriconazole
- Contraindications for Voriconazole
- How to use Voriconazole
Voriconazole is the active substance in an antifungal medicine known commercially as Vfend.
This oral medication is injectable and is indicated for the treatment of aspergillosis, since its action interferes with ergosterol, an essential substance for maintaining the integrity of the fungal cell membrane, which ends up weakened and eliminated from the body.
Indications for Voriconazole
Aspergillosis; severe fungal infection.
Voriconazole price
The 200 mg box of Voriconazole containing an ampoule costs approximately 1, 200 reais, the 200 mg oral box containing 14 tablets costs approximately 5, 000 reais.
Side Effects of Voriconazole
Increased creatinine; visual disturbances (alteration or increase in visual perception; blurred vision; change in vision colors; sensitivity to light).
Contraindications for Voriconazole
Pregnancy Risk D; lactating women; hypersensitivity to the product or other azoles; galactose intolerance; lactase deficiency.
How to use Voriconazole
Injectable Use
Intravenous infusion.
Adults
- Attack dose: 6 mg per kg of body weight every 12 hours for 2 doses, followed by a maintenance dose of 4 mg per kg of body weight every 12 hours. As soon as possible (as long as the patient tolerates), switch to oral. If the patient does not tolerate, reduce to 3 mg per kg of body weight every 12 h. Elderly: same dose as adults. Patients with mild to moderate liver failure: halve the maintenance dose. Patients with severe liver cirrhosis: use only if the benefits outweigh the risks. Children up to 12 years of age: safety and efficacy not established.
Oral use
Adults
- With over 40 kg of weight: The maintenance dose is 200 mg every 12 hours, if the response is not adequate, the dose can be increased to 300 mg every 12 hours (if the patient does not tolerate, perform increments of 50 mg every 12 hours). At 40 kg less: The maintenance dose of 100 mg every 12 hours, if the response is not adequate, the dose can be increased to 150 mg for every 12 hours (if the patient does not tolerate, reduce to 100 mg each 12 hours). Patients with hepatic impairment: dose reduction may be necessary. Elderly: same doses as adults. Children up to 12 years of age: safety and efficacy not established.
