Trimetazidine is an active substance indicated for the treatment of ischemic heart failure and ischemic heart disease, which is a disease caused by a deficiency in blood circulation in the arteries.
Trimetazidine can be purchased in pharmacies for a price of about 45 to 107 reais, upon presentation of a prescription.
How to use
The recommended dosage is 1 35 mg tablet, twice a day, once in the morning, during breakfast and once in the evening, during dinner.
What is the mechanism of action
Trimetazidine preserves the energy metabolism of ischemic cells, exposed to low oxygen concentration, preventing the decrease in intracellular levels of ATP (energy), thus ensuring the proper functioning of ionic pumps and the transmembrane flow of sodium and potassium, while maintaining homeostasis cell phone.
This preservation of energy metabolism is achieved by the inhibition of β-oxidation of fatty acids, exerted by trimetazidine, which increases the oxidation of glucose, which is a way of obtaining energy that requires less oxygen consumption compared to the β-oxidation process.. Thus, the potentiation of glucose oxidation optimizes the cellular energy process, maintaining the appropriate energy metabolism during ischemia.
In patients with ischemic heart disease, trimetazidine acts as a metabolic agent preserving the intracellular levels of high myocardial phosphates.
Who should not use
This medicine is contraindicated in patients with hypersensitivity to trimetazidine or any of the components of the formula, people with Parkinson's disease, symptoms of parkinsonism, tremors, restless leg syndrome and other changes related to movement and with severe renal failure with clearance creatinine less than 30mL / min.
In addition, this medicine should also not be used by children under 18, pregnant women or women who are breastfeeding.
Possible side effects
Some of the most common side effects that may occur during treatment with trimetazidine are dizziness, headache, abdominal pain, diarrhea, poor digestion, nausea, vomiting, rash, itching, hives and weakness.
