Zavesca is a medicine that contains miglustat, a substance capable of preventing the action of an enzyme that produces glycosphingolipids, a type of fat that accumulates in the body. In this way, it is possible to relieve the symptoms of Niemann-Pick disease, in which fats accumulate in various parts of the body.
This remedy is produced by Actelion laboratories in the form of capsules with 100 mg each.
Price and where to buy
Zavesca can be purchased at some pharmacies or purchased through the hospital, after presenting a prescription, and its price is approximately 27 thousand reais, for each pack of 90 capsules.
What is it for
This remedy is indicated to relieve neurological symptoms caused by type C Niemann-Pick disease, such as seizures, loss of mental capacity or lack of coordination, for example.
In addition, this medication can also be used to treat mild to moderate Gaucher disease type 1.
How to take
The dose, time and duration of treatment should always be guided by a doctor, according to each case. However, the general guidelines indicate:
- Adults with type 1 Gaucher disease: initial dose of 100 mg 3 times a day, which can be adjusted by the doctor according to the effects; Adults and children over 12 years old, with Niemann-Pick disease type C: 200 mg, 3 times a day; Children with Niemann-Pick disease and less than 12 years old:
| Body surface area | Recommended dose |
| > 1.25 m² | 200 mg, 3 times a day |
| > 0.88 to 1.25 m² | 200 mg twice a day |
| > 0.73 to 0.88 m² | 100 mg, 3 times a day |
| > 0.47 to 0.73 m² | 100 mg twice a day |
| <0.47 | 100 mg, 1 times a day |
Possible side effects
Some of the most common side effects of using zavesca include weight loss, decreased appetite, depression, insomnia, decreased libido, tremors, amnesia, headaches, dizziness, diarrhea, excess intestinal gas, vomiting, nausea, belly, tiredness and chills.
Who should not take
Zavesca is contraindicated for pregnant women, breastfeeding women and people with allergies to any of the components of the formula.
