Tideglusib is a drug still under testing for the treatment of Alzheimer's disease and other neurological diseases, such as Progressive Supranuclear Palsy. Its main action is the ability to inhibit the action of the GSK-3 protein, thus preventing the phosphorylation of the Tau protein and preventing the accumulation of tangles of proteins toxic to the brain, which cause various brain diseases.
In addition, it has also been discovered that this active ingredient is capable of regenerating dentin and pulp of teeth, after tooth wear, and may reduce the need for procedures such as filling.
However, because it is still in the testing phase, this drug cannot be commercialized yet, until the tests are finalized and it is approved for use in the treatment of people.
What is it for
Some of the possible actions of Tideglusib include the treatment of:
- Alzheimer's disease; Progressive supranuclear palsy; Repair of tooth wear by strengthening dentin; Autism in adolescents; Congenital Myotonic Muscular Dystrophy.
However, these effects are still being tested in scientific studies that assess efficacy and safety in humans.
Main effects
The main effects observed so far of Tideglusib are the reduction of several effects in the brain of Alzheimer's disease and other neurological diseases, such as phosphorylation of the Tau protein, deposition of amyloid proteins, death of neurons and brain mass, which can help reverse memory loss. In addition, this medicine can have anti-inflammatory, neuroprotective and stimulate the formation of brain neurons. Check out the main treatments currently available for Alzheimer's.
Another important effect of this medication is the capacity of regeneration in the pulp of the teeth, which can help in the treatment of tooth wear due to cavities without the need for filling. This effect has been demonstrated in rats, after applying biodegradable collagen sponges embedded in a compound containing Tideglusib, which stimulated the multiplication of tooth pulp stem cells to cover cavities in cavities. Also understand how cavities are treated and when filling is still needed.
